The present investigation describes development of floating hydrogels of pantoprazole sodium using hydrophilic polymers like HPMC K100M, HPMC K4M and HPMC E50LV, Sodium alginate as gelling agent, sodium bicarbonate as gas generating agent using continuous stirring method. Twelve formulations were prepared in this study. Physical observation at room conditions (temp, RH) and fourier transform infrared spectroscopy (FTIR) concluded that there was no chemical interaction between drug and excipients used. Prepared floating hydrogels were evaluated for various evaluation parameters like pH, gelation studies, viscosity studies, drug content studies, swelling index, floating lag time studies and in-vitro drug release. Dissolution studies were carried out in 0.1 N HCl upto 12 hrs. In this investigation it was confirmed that the release rate from the floating hydrogels which were prepared by HPMC K4M and HPMC K100M shown better controlled release than others. The result of formulation F11 was 98.29% at the end of 12 hrs. All formulations showed non-fickian diffusion controlled zero order kinetics.
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